Ok so talking with the manufacturer I now have more detailed info about this. So obviously with ANY pressurized cylinder, it should be handled with extreme caution no matter the gas contained within it (CO2 or Air). With that said, The joint between the tank and the valve is very robust. This is the same thread design used on firefighter tanks in Europe & Asia (US firefighters are slowly moving to this thread design as well) and they have these strapped to their backs. It is equipped with a ASTM safety groove to vent the air in the event that the valve is removed with air still in the tank or if the regulator breaks off of the tank. In other words, your safe even with a catastrophic failure. The regulator can be unscrewed and removed from the tank valve. This reduces the height of the system, allows the regulator to stay warm in the cab of the truck while the tank is in the bed, and helps to prevent system damage. Please see the picture of the system with the regulator removed. Being that it only takes a few seconds to remove the regulator, we recommend keeping it off while the tank is not needed and keep it with the rest of your air supply gear.